Transcatheter Aortic Valve Implantation in Lower-Risk Patients With Aortic Stenosis: Is It Justified to Be the Preferred Treatment?

Circ Cardiovasc Interv. 2016 Apr;9(4):e002944. doi: 10.1161/CIRCINTERVENTIONS.115.002944.

Abstract

Transcatheter aortic valve implantation underwent progressive improvements until it became the default therapy for inoperable patients, and a recommended therapy in high-risk operable patients with symptomatic severe aortic stenosis. In the lower-risk patient strata, a currently costly therapy that still has important complications with questionable durability is competing with the established effective and still-improving surgical replacement. This report tries to weigh the clinical evidence, the recent technical improvements, the durability, and the cost-effectiveness claims supporting the adoption of transcatheter aortic valve implantation in intermediate-low risk patients. The importance of appropriate patients' risk stratification and a more comprehensive approach to estimate that risk are also emphasized in the present report.

Keywords: aortic valve stenosis; heart valve prosthesis implantation; risk assessment; transcatheter aortic valve replacement.

Publication types

  • Review

MeSH terms

  • Aortic Valve / physiopathology
  • Aortic Valve / surgery*
  • Aortic Valve Stenosis / mortality
  • Aortic Valve Stenosis / physiopathology
  • Aortic Valve Stenosis / surgery
  • Aortic Valve Stenosis / therapy*
  • Cardiac Catheterization* / adverse effects
  • Cardiac Catheterization* / economics
  • Cardiac Catheterization* / instrumentation
  • Cardiac Catheterization* / mortality
  • Cost-Benefit Analysis
  • Decision Support Techniques
  • Health Care Costs
  • Heart Valve Prosthesis Implantation* / adverse effects
  • Heart Valve Prosthesis Implantation* / economics
  • Heart Valve Prosthesis Implantation* / instrumentation
  • Heart Valve Prosthesis Implantation* / mortality
  • Humans
  • Patient Selection*
  • Postoperative Complications
  • Risk Assessment
  • Risk Factors
  • Treatment Outcome