Clinical InvestigationVentricular and Atrial FunctionRight Ventricular Regional Systolic Function and Dyssynchrony in Patients with Pulmonary Hypertension Evaluated by Three-Dimensional Echocardiography
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Study Population
A total of 70 consecutive patients with PH (22 men; mean age, 41 ± 15 years) were enrolled in this study. Patients were admitted to the Division of Cardiology or the Division of Cardiac Surgery at Zhongshan Hospital of Fudan University from December 2010 to April 2011. Forty-seven patients were diagnosed with pulmonary arterial hypertension (six idiopathic, 27 with atrial septal defects, eight with ventricular septal defects, and six with patent ductus arteriosus), and 23 patients were
Clinical and Conventional Echocardiographic Characteristics
Conventional echocardiographic images were successfully obtained and analyzed in all subjects. Clinical and conventional echocardiographic characteristics of the study population are summarized in Table 1. There were no significant differences in age, gender, peak tissue Doppler systolic velocity of the tricuspid annulus, and left ventricular EF between the PH groups and the control group. Heart rates in the moderate and severe PH groups were higher than in the control group. RV end-diastolic
Discussion
The present study demonstrated regional characteristics of RV systolic function evaluated by RT3DE in patients with PH. We found that RV inflow and global systolic function were impaired in inverse relationship with PASP and PVR in patients with PH and that RV systolic synchronicity was impaired in severe PH. These findings suggest that the evaluation of RV regional systolic function using RT3DE may play a potential role in the noninvasive assessment of the severity of PH. To our knowledge,
Conclusions
The present study demonstrated that the use of RT3DE is feasible in the quantification of RV regional systolic function and dyssynchrony in patients with PH. We found that the early impairment of RV regional systolic function could be detected by RT3DE. RV inflow and global systolic function were impaired in inverse relationship with PASP and PVR in patients with PH, and RV systolic synchronicity was impaired in patients with severe PH. These findings suggest that the evaluation of RV regional
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This study was supported by grants 81000614 and 30972812 from National Natural Science Foundation of China, grant XYQ2011056 from the Shanghai Outstanding Young Scientist Project, grant 416 from the Youth Foundation of Zhongshan Hospital, and grant Y-2013-15 from the Youth Foundation of Shanghai Institute of Medical Imaging.