Quality of life is impaired similarly in heart failure patients with preserved and reduced ejection fraction

Eur J Heart Fail. 2011 Sep;13(9):1013-8. doi: 10.1093/eurjhf/hfr072. Epub 2011 Jun 28.

Abstract

Aims: To compare quality of life (QoL) in heart failure (HF) patients with preserved ejection fraction (HF-PEF) and HF patients with reduced ejection fraction (HF-REF) in a well-defined HF population.

Methods and results: Patients with HF-PEF [left ventricular ejection fraction (LVEF) ≥40%] were matched by age and gender to patients with HF-REF (LVEF <40%). In the current study, we only included HF patients with a B-type natriuretic peptide level (BNP) >100 pg/mL. Quality of life was assessed by Cantril's Ladder of Life, RAND-36, and the Minnesota Living with Heart Failure questionnaire, and impairment of QoL was adjusted for by BNP as a marker for severity of HF. We examined a total of 290 HF patients, of whom 145 had HF-PEF (41% female; age 72 ± 10; LVEF 51 ± 8%) and 145 had HF-REF (41% female; age 73 ± 10, LVEF 26 ± 7%). All HF patients reported markedly low scores of QoL, both on the general and disease-specific QoL questionnaires. Quality of life between patients with HF-PEF and HF-REF did not differ significantly. When adjusting the QoL scores for BNP, an association between QoL and LVEF was not found, i.e. patients with HF-PEF and HF-REF with similar BNP levels had the same impairment in QoL.

Conclusion: Quality of life is similarly impaired in patients with HF-PEF as in HF-REF. These findings further support the need for more pharmacological and non-pharmacological studies in patients with HF-PEF.

Trial registration number: NCT 98675639.

Trial registration: ClinicalTrials.gov NCT98675639.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Female
  • Heart Failure / blood
  • Heart Failure / physiopathology*
  • Humans
  • Male
  • Natriuretic Peptide, Brain / blood
  • Quality of Life*
  • Severity of Illness Index
  • Stroke Volume
  • Surveys and Questionnaires
  • Ventricular Dysfunction, Left / blood
  • Ventricular Dysfunction, Left / physiopathology*

Substances

  • Natriuretic Peptide, Brain

Associated data

  • ClinicalTrials.gov/NCT98675639