Coronary artery diseaseUsefulness of Coronary Pressure Measurement for Functional Evaluation of Drug-Eluting Stent Restenosis
Section snippets
Methods
The present prospective observational study enrolled patients from 6 interventional centers in Korea who had undergone measurement of coronary pressure-derived FFR to assess the functional significance of restenotic lesions (visual percentage diameter stenosis [%DS] ≥40% in stent or 5 mm adjacent to either of the 2 stent edges) after DES implantation. The lesion should have no documented evidence of associated ischemia on noninvasive tests (not performed, negative, inadequate, or not evaluable
Results
To assess functional severity, the FFR was measured in 50 restenotic lesions (49 patients) after DES implantation. Of the 49 patients, 31 were referred to the catheterization laboratory without a previous noninvasive test, including 38% of the symptomatic patients. The others had had nondiagnostic test results. Three type of DESs were implanted at the index procedure: sirolimus-eluting stents, paclitaxel-eluting stents, and zotarolimus-eluting stents (34%, 53%, and 13% respectively). The mean
Discussion
The major findings in the present study were that a discrepancy exists between functional ischemia measured by FFR and angiographic %DS, in particular, in moderate- or diffuse-type restenotic lesions after DES implantation, and FFR-guided intervention can be used to determine the treatment of these lesions.
Because the patients with DES restenosis had a greater prevalence of diabetes and a larger stent length, together with the expectation that the final result obtained after treatment of the
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This study was supported by research grant 2010-02 from the Korean Society of Interventional Cardiology, Seoul, Korea.