Clinical InvestigationCarotid AtherosclerosisA Longitudinal Study of Carotid Plaque and Risk of Ischemic Cardiovascular Disease in the Chinese Population
Section snippets
Study Population
The study population was composed of two cohorts in Beijing, one rural (Shijingshan district cohort) and one urban (Peking University community cohort).
The former was taken from the study population of the third survey of the People’s Republic of China/United States of America Collaborative Study of Cardiovascular & Cardiopulmonary Epidemiology in 1993 and 1994.10, 11 This cohort consisted of a cluster random sample of 2,313 participants from all 11 rural communities in Beijing’s Shijingshan
Baseline Characteristics
During a mean follow-up period of 4 years (12,901 person-years in total), there were 87 new cases of ischemic stroke (42 in men and 45 in women) and 57 of CHD (23 in men and 34 in women), and a total of 137 participants had new ICVD events (63 in men and 74 in women). The incidence rate was 6.7 per 1,000 person-years for ischemic stroke (8.0 in men and 5.9 in women), 4.4 per 1,000 person-years for CHD (4.4 in men and 4.4 in women), and 10.6 per 1,000 person-years for ICVD events (12.0 in men
Primary Findings
The present study demonstrated that the presence of carotid plaque was significantly associated with the subsequent incidence of ICVD events, and a dose-response relationship existed between risk for ICVD and TPS. The same findings was reported previously in only two large-scale and population-based prospective studies, one in the Netherlands and the other in the United States.5, 7, 8 In the Rotterdam Study, the age-adjusted and sex-adjusted HR of myocardial infarction was 2.45 (95% CI,
Conclusions
In our study, carotid plaque provided important additional information about future risk for ICVD events in the Chinese general population and represents a simple and inexpensive screening tool to estimate cardiovascular risk for preventive strategies. Plaque in the CCA may bear more clinical significance than that in the bifurcation in predicting subsequent ICVD risk.
Acknowledgment
We deeply appreciate the participation of our colleagues and especially the contribution of the research participants in these studies.
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This study was supported by the People’s Republic of China Ministry of Science and Technology and the Ministry of Health through the 10th and 11th National Five-Year Plan Projects (contracts 2001BA703B01 and 2006BAI01A02).