Clinical InvestigationSerum Levels of High-Sensitivity Troponin T: A Novel Marker for Cardiac Remodeling in Hypertrophic Cardiomyopathy
Section snippets
Patients and Methods
We included 95 HCM stable patients attending a cardiology outpatient clinic for routine follow-up, from two referral hospitals in Spain (Hospital Universitario Virgen de la Arrixaca, Murcia, and Hospital General Universitario, Alicante), aged 45.7 ± 14.2 years old and 72 (75.8%) of them male. The criteria for diagnosis of HCM was the presence of a LV wall thickness of ≥15 mm without any other cause that could lead to ventricular hypertrophy, and in the case of first-degree relatives of affected
Results
Clinical data of patients are presented in Table 1. Fifty-three patients (55.7%) showed impaired functional class (NYHA ≥II), and only six patients presented systolic dysfunction (6.3%). Forty-three patients (45%) presented angina, and sixty-nine patients (72.6%) showed late gadolinium enhancement assessed by cardiac MRI.
Discussion
This study showed that hs-TnT serum levels were elevated in up to 42% of our cohort of patients with HCM, and in only 4.4% of healthy paired control subjects. Importantly, the HCM patients were stable patients attending to routine follow-up in our referral outpatient clinics. This elevation may reflect a continuous myocyte loss due to a moderate range of necrosis, and it is associated with parameters of HCM severity as the functional class, systolic dysfunction, and fibrosis assessed by cardiac
Disclosures
None.
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Cited by (0)
Funding: Supported by an FIS PS09/00721 project for the Instituto de Salud Carlos III, and in part by Funding FEDER and by Roche Diagnostics. Dr Hernández-Romero holds a postdoctoral position funded by the Instituto de Salud Carlos III.
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