A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project

Circ Cardiovasc Genet. 2009 Aug;2(4):322-8. doi: 10.1161/CIRCGENETICS.108.833806. Epub 2009 May 15.

Abstract

Background: We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations.

Methods and results: We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P=3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P=2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P=4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval.

Conclusions: Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adult
  • Aged
  • Chromosomes, Human, Pair 13
  • Electrocardiography*
  • Female
  • Genome-Wide Association Study
  • Genotype
  • Heart Rate / genetics*
  • Humans
  • Male
  • Middle Aged
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Receptors, G-Protein-Coupled / genetics
  • White People / genetics*

Substances

  • ADGRD1 protein, human
  • Adaptor Proteins, Signal Transducing
  • NOS1AP protein, human
  • Receptors, G-Protein-Coupled