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Abstract

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura.

Scully M, Cataland SR, Peyvandi F, Coppo P, ... Zeldin RK,
In acquired thrombotic thrombocytopenic purpura (TTP), an immune-mediated deficiency of the von Willebrand factor-cleaving protease ADAMTS13 allows unrestrained adhesion of von Willebrand factor multimers to platelets and microthrombosis, which result in thrombocytopenia, hemolytic anemia, and tissue ischemia. Caplacizumab, an anti-von Willebrand factor humanized, bivalent variable-domain-only immunoglobulin fragment, inhibits interaction between von Willebrand factor multimers and platelets.

N Engl J Med: 23 Jan 2019; 380:335-346
Scully M, Cataland SR, Peyvandi F, Coppo P, ... Zeldin RK,
N Engl J Med: 23 Jan 2019; 380:335-346 | PMID: 30625070
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Abstract

Separation of Craniopagus Twins by a Multidisciplinary Team.

Heuer GG, Madsen PJ, Flanders TM, Kennedy BC, Storm PB, Taylor JA
Conjoined twins who are classified as craniopagus (joined at the cranium) have a rare congenital anomaly. Despite advances in surgical techniques and critical care, the rate of complications and death is still high among twins with total fusion in which the superior sagittal sinus is shared. Here, we describe total-fusion craniopagus twins who at 10 months of age underwent successful surgical separation performed by a multidisciplinary team. Computer-aided design and modeling with a three-dimensional printer, custom-designed cranial distraction and constriction devices, and intraoperative navigation techniques were used. These techniques allowed for separation of the twins at an early age and harnessed the regenerative capacity of their young brains.

N Engl J Med: 23 Jan 2019; 380:358-364
Heuer GG, Madsen PJ, Flanders TM, Kennedy BC, Storm PB, Taylor JA
N Engl J Med: 23 Jan 2019; 380:358-364 | PMID: 30673542
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Abstract

Plerixafor for the Treatment of WHIM Syndrome.

McDermott DH, Pastrana DV, Calvo KR, Pittaluga S, ... Buck CB, Murphy PM
WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis), a primary immunodeficiency disorder involving panleukopenia, is caused by autosomal dominant gain-of-function mutations in CXC chemokine receptor 4 (CXCR4). Myelokathexis is neutropenia caused by neutrophil retention in bone marrow. Patients with WHIM syndrome are often treated with granulocyte colony-stimulating factor (G-CSF), which can increase neutrophil counts but does not affect cytopenias other than neutropenia. In this investigator-initiated, open-label study, three severely affected patients with WHIM syndrome who could not receive G-CSF were treated with low-dose plerixafor, a CXCR4 antagonist, for 19 to 52 months. Myelofibrosis, panleukopenia, anemia, and thrombocytopenia were ameliorated, the wart burden and frequency of infection declined, human papillomavirus-associated oropharyngeal squamous-cell carcinoma stabilized, and quality of life improved markedly. Adverse events were mainly infections attributable to the underlying immunodeficiency. One patient died from complications of elective reconstructive surgery. (Funded by the National Institutes of Health.).

N Engl J Med: 09 Jan 2019; 380:163-170
McDermott DH, Pastrana DV, Calvo KR, Pittaluga S, ... Buck CB, Murphy PM
N Engl J Med: 09 Jan 2019; 380:163-170 | PMID: 30625055
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Abstract

Randomized Trial of Verubecestat for Prodromal Alzheimer\'s Disease.

Egan MF, Kost J, Voss T, Mukai Y, ... Sur C, Michelson D
Prodromal Alzheimer\'s disease offers an opportunity to test the effect of drugs that modify the deposition of amyloid in the brain before the onset of dementia. Verubecestat is an orally administered β-site amyloid precursor protein-cleaving enzyme 1 (BACE-1) inhibitor that blocks production of amyloid-beta (Aβ). The drug did not prevent clinical progression in a trial involving patients with mild-to-moderate dementia due to Alzheimer\'s disease.

N Engl J Med: 10 Apr 2019; 380:1408-1420
Egan MF, Kost J, Voss T, Mukai Y, ... Sur C, Michelson D
N Engl J Med: 10 Apr 2019; 380:1408-1420 | PMID: 30970186
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Abstract

Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer.

Bardia A, Mayer IA, Vahdat LT, Tolaney SM, ... Wegener WA, Kalinsky K
Standard chemotherapy is associated with low response rates and short progression-free survival among patients with pretreated metastatic triple-negative breast cancer. Sacituzumab govitecan-hziy is an antibody-drug conjugate that combines a humanized monoclonal antibody, which targets the human trophoblast cell-surface antigen 2 (Trop-2), with SN-38, which is conjugated to the antibody by a cleavable linker. Sacituzumab govitecan-hziy enables delivery of high concentrations of SN-38 to tumors.

N Engl J Med: 20 Jan 2019; 380:741-751
Bardia A, Mayer IA, Vahdat LT, Tolaney SM, ... Wegener WA, Kalinsky K
N Engl J Med: 20 Jan 2019; 380:741-751 | PMID: 30786188
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Abstract

Apixaban to Prevent Venous Thromboembolism in Patients with Cancer.

Carrier M, Abou-Nassar K, Mallick R, Tagalakis V, ... Wells PS,
Patients with active cancer have an increased risk of venous thromboembolism, which results in substantial morbidity, mortality, and health care expenditures. The Khorana score (range, 0 to 6, with higher scores indicating a higher risk of venous thromboembolism) has been validated to identify patients with cancer at elevated risk for this complication and may help select those who could benefit from thromboprophylaxis.

N Engl J Med: 20 Jan 2019; 380:711-719
Carrier M, Abou-Nassar K, Mallick R, Tagalakis V, ... Wells PS,
N Engl J Med: 20 Jan 2019; 380:711-719 | PMID: 30511879
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Abstract

Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer.

von Minckwitz G, Huang CS, Mano MS, Loibl S, ... Geyer CE,
Patients who have residual invasive breast cancer after receiving neoadjuvant chemotherapy plus human epidermal growth factor receptor 2 (HER2)-targeted therapy have a worse prognosis than those who have no residual cancer. Trastuzumab emtansine (T-DM1), an antibody-drug conjugate of trastuzumab and the cytotoxic agent emtansine (DM1), a maytansine derivative and microtubule inhibitor, provides benefit in patients with metastatic breast cancer that was previously treated with chemotherapy plus HER2-targeted therapy.

N Engl J Med: 13 Jan 2019; 380:617-628
von Minckwitz G, Huang CS, Mano MS, Loibl S, ... Geyer CE,
N Engl J Med: 13 Jan 2019; 380:617-628 | PMID: 30516102
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Abstract

Psychosis with Methylphenidate or Amphetamine in Patients with ADHD.

Moran LV, Ongur D, Hsu J, Castro VM, Perlis RH, Schneeweiss S
The prescription use of the stimulants methylphenidate and amphetamine for the treatment of attention deficit-hyperactivity disorder (ADHD) has been increasing. In 2007, the Food and Drug Administration mandated changes to drug labels for stimulants on the basis of findings of new-onset psychosis. Whether the risk of psychosis in adolescents and young adults with ADHD differs among various stimulants has not been extensively studied.

N Engl J Med: 20 Jan 2019; 380:1128-1138
Moran LV, Ongur D, Hsu J, Castro VM, Perlis RH, Schneeweiss S
N Engl J Med: 20 Jan 2019; 380:1128-1138 | PMID: 30893533
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Abstract

Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism.

van der Pol LM, Tromeur C, Bistervels IM, Ni Ainle F, ... Huisman MV,
Pulmonary embolism is one of the leading causes of maternal death in the Western world. Because of the low specificity and sensitivity of the d-dimer test, all pregnant women with suspected pulmonary embolism undergo computed tomographic (CT) pulmonary angiography or ventilation-perfusion scanning, both of which involve radiation exposure to the mother and fetus. Whether a pregnancy-adapted algorithm could be used to safely avoid diagnostic imaging in pregnant women with suspected pulmonary embolism is unknown.

N Engl J Med: 20 Jan 2019; 380:1139-1149
van der Pol LM, Tromeur C, Bistervels IM, Ni Ainle F, ... Huisman MV,
N Engl J Med: 20 Jan 2019; 380:1139-1149 | PMID: 30893534
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Abstract

Vitamin D-Binding Protein Deficiency and Homozygous Deletion of the Gene.

Henderson CM, Fink SL, Bassyouni H, Argiropoulos B, ... Hoofnagle AN, Marcadier JL
A 58-year-old woman with debilitating ankylosing spondylitis who was born to consanguineous parents was found to have an apparent severe vitamin D deficiency that did not respond to supplementation. Liquid chromatography-tandem mass spectrometry showed the absence of circulating vitamin D-binding protein, and chromosomal microarray confirmed a homozygous deletion of the group-specific component () gene that encodes the protein. Congenital absence of vitamin D-binding protein resulted in normocalcemia and a relatively mild disruption of bone metabolism, in this case complicated by severe autoimmune disease. (Funded by the National Institutes of Health and the University of Washington.).

N Engl J Med: 20 Jan 2019; 380:1150-1157
Henderson CM, Fink SL, Bassyouni H, Argiropoulos B, ... Hoofnagle AN, Marcadier JL
N Engl J Med: 20 Jan 2019; 380:1150-1157 | PMID: 30893535
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Abstract

Overall Survival with Fulvestrant plus Anastrozole in Metastatic Breast Cancer.

Mehta RS, Barlow WE, Albain KS, Vandenberg TA, ... Livingston RB, Hortobagyi GN
We previously reported prolonged progression-free survival and marginally prolonged overall survival among postmenopausal patients with hormone receptor-positive metastatic breast cancer who had been randomly assigned to receive the aromatase inhibitor anastrozole plus the selective estrogen-receptor down-regulator fulvestrant, as compared with anastrozole alone, as first-line therapy. We now report final survival outcomes.

N Engl J Med: 27 Jan 2019; 380:1226-1234
Mehta RS, Barlow WE, Albain KS, Vandenberg TA, ... Livingston RB, Hortobagyi GN
N Engl J Med: 27 Jan 2019; 380:1226-1234 | PMID: 30917258
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Abstract

Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy.

Cortese I, Muranski P, Enose-Akahata Y, Ha SK, ... Reich DS, Nath A
Progressive multifocal leukoencephalopathy (PML) is an opportunistic brain infection that is caused by the JC virus and is typically fatal unless immune function can be restored. Programmed cell death protein 1 (PD-1) is a negative regulator of the immune response that may contribute to impaired viral clearance. Whether PD-1 blockade with pembrolizumab could reinvigorate anti-JC virus immune activity in patients with PML was unknown.

N Engl J Med: 24 Jan 2019; 380:1597-1605
Cortese I, Muranski P, Enose-Akahata Y, Ha SK, ... Reich DS, Nath A
N Engl J Med: 24 Jan 2019; 380:1597-1605 | PMID: 30969503
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Abstract

Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.

Mamcarz E, Zhou S, Lockey T, Abdelsamed H, ... Cowan MJ, Sorrentino BP
Allogeneic hematopoietic stem-cell transplantation for X-linked severe combined immunodeficiency (SCID-X1) often fails to reconstitute immunity associated with T cells, B cells, and natural killer (NK) cells when matched sibling donors are unavailable unless high-dose chemotherapy is given. In previous studies, autologous gene therapy with γ-retroviral vectors failed to reconstitute B-cell and NK-cell immunity and was complicated by vector-related leukemia.

N Engl J Med: 17 Jan 2019; 380:1525-1534
Mamcarz E, Zhou S, Lockey T, Abdelsamed H, ... Cowan MJ, Sorrentino BP
N Engl J Med: 17 Jan 2019; 380:1525-1534 | PMID: 30995372
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Abstract

Effect of Anti-CD4 Antibody UB-421 on HIV-1 Rebound after Treatment Interruption.

Wang CY, Wong WW, Tsai HC, Chen YH, ... Chun TW, Liao MJ
Administration of a single broadly neutralizing human immunodeficiency virus (HIV)-specific antibody to HIV-infected persons leads to the development of antibody-resistant virus in the absence of antiretroviral therapy (ART). It is possible that monotherapy with UB-421, an antibody that blocks the virus-binding site on human CD4+ T cells, could induce sustained virologic suppression without induction of resistance in HIV-infected persons after analytic treatment interruption.

N Engl J Med: 17 Jan 2019; 380:1535-1545
Wang CY, Wong WW, Tsai HC, Chen YH, ... Chun TW, Liao MJ
N Engl J Med: 17 Jan 2019; 380:1535-1545 | PMID: 30995373
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Abstract

Open versus Endovascular Repair of Abdominal Aortic Aneurysm.

Lederle FA, Kyriakides TC, Stroupe KT, Freischlag JA, ... Johnson GR,
Elective endovascular repair of an abdominal aortic aneurysm results in lower perioperative mortality than traditional open repair, but after 4 years this survival advantage is not seen; in addition, results of two European trials have shown worse long-term outcomes with endovascular repair than with open repair. Long-term results of a study we conducted more than a decade ago to compare endovascular repair with open repair are unknown.

N Engl J Med: 29 Jan 2019; 380:2126-2135
Lederle FA, Kyriakides TC, Stroupe KT, Freischlag JA, ... Johnson GR,
N Engl J Med: 29 Jan 2019; 380:2126-2135 | PMID: 31141634
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Abstract

Controlled Trial of Budesonide-Formoterol as Needed for Mild Asthma.

Beasley R, Holliday M, Reddel HK, Braithwaite I, ... Weatherall M,
In double-blind, placebo-controlled trials, budesonide-formoterol used on an as-needed basis resulted in a lower risk of severe exacerbation of asthma than as-needed use of a short-acting β-agonist (SABA); the risk was similar to that of budesonide maintenance therapy plus as-needed SABA. The availability of data from clinical trials designed to better reflect clinical practice would be beneficial.

N Engl J Med: 22 Jan 2019; 380:2020-2030
Beasley R, Holliday M, Reddel HK, Braithwaite I, ... Weatherall M,
N Engl J Med: 22 Jan 2019; 380:2020-2030 | PMID: 31112386
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Abstract

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in .

van Kuilenburg ABP, Tarailo-Graovac M, Richmond PA, Drögemöller BI, ... Usdin K, van Karnebeek CDM
We report an inborn error of metabolism caused by an expansion of a GCA-repeat tract in the 5\' untranslated region of the gene encoding glutaminase () that was identified through detailed clinical and biochemical phenotyping, combined with whole-genome sequencing. The expansion was observed in three unrelated patients who presented with an early-onset delay in overall development, progressive ataxia, and elevated levels of glutamine. In addition to ataxia, one patient also showed cerebellar atrophy. The expansion was associated with a relative deficiency of messenger RNA transcribed from the expanded allele, which probably resulted from repeat-mediated chromatin changes upstream of the repeat. Our discovery underscores the importance of careful examination of regions of the genome that are typically excluded from or poorly captured by exome sequencing.

N Engl J Med: 10 Jan 2019; 380:1433-1441
van Kuilenburg ABP, Tarailo-Graovac M, Richmond PA, Drögemöller BI, ... Usdin K, van Karnebeek CDM
N Engl J Med: 10 Jan 2019; 380:1433-1441 | PMID: 30970188
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Abstract

Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source.

Diener HC, Sacco RL, Easton JD, Granger CB, ... Toyoda K,
Cryptogenic strokes constitute 20 to 30% of ischemic strokes, and most cryptogenic strokes are considered to be embolic and of undetermined source. An earlier randomized trial showed that rivaroxaban is no more effective than aspirin in preventing recurrent stroke after a presumed embolic stroke from an undetermined source. Whether dabigatran would be effective in preventing recurrent strokes after this type of stroke was unclear.

N Engl J Med: 15 Jan 2019; 380:1906-1917
Diener HC, Sacco RL, Easton JD, Granger CB, ... Toyoda K,
N Engl J Med: 15 Jan 2019; 380:1906-1917 | PMID: 31091372
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Abstract

Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers.

Bhatt DL, Pollack CV, Weitz JI, Jennings LK, ... Mays MC, Lee JS
Ticagrelor is an oral P2Y inhibitor that is used with aspirin to reduce the risk of ischemic events among patients with acute coronary syndromes or previous myocardial infarction. Spontaneous major bleeding and bleeding associated with urgent invasive procedures are concerns with ticagrelor, as with other antiplatelet drugs. The antiplatelet effects of ticagrelor cannot be reversed with platelet transfusion. A rapid-acting reversal agent would be useful.

N Engl J Med: 08 Jan 2019; 380:1825-1833
Bhatt DL, Pollack CV, Weitz JI, Jennings LK, ... Mays MC, Lee JS
N Engl J Med: 08 Jan 2019; 380:1825-1833 | PMID: 30883047
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Abstract

Mesenchymal Hamartoma of the Liver and DICER1 Syndrome.

Apellaniz-Ruiz M, Segni M, Kettwig M, Glüer S, ... Priest JR, Foulkes WD
Mesenchymal hamartoma of the liver (MHL) is a benign tumor affecting children that is characterized by a primitive myxoid stroma with cystically dilated bile ducts. Alterations involving chromosome 19q13 are a recurrent underlying cause of MHL; these alterations activate the chromosome 19 microRNA cluster (C19MC). Other cases remain unexplained. We describe two children with MHLs that harbored germline pathogenic variants. Analysis of tumor tissue from one of the children revealed two \"hits.\" Mutations in dysregulate microRNAs, mimicking the effect of the activation of C19MC. Our data suggest that MHL is a new phenotype of DICER1 syndrome. (Funded by the Canadian Institutes of Health Research and others.).

N Engl J Med: 08 Jan 2019; 380:1834-1842
Apellaniz-Ruiz M, Segni M, Kettwig M, Glüer S, ... Priest JR, Foulkes WD
N Engl J Med: 08 Jan 2019; 380:1834-1842 | PMID: 31067372
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Abstract

Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease.

Nagel E, Greenwood JP, McCann GP, Bettencourt N, ... Berry C,
In patients with stable angina, two strategies are often used to guide revascularization: one involves myocardial-perfusion cardiovascular magnetic resonance imaging (MRI), and the other involves invasive angiography and measurement of fractional flow reserve (FFR). Whether a cardiovascular MRI-based strategy is noninferior to an FFR-based strategy with respect to major adverse cardiac events has not been established.

N Engl J Med: 19 Jan 2019; 380:2418-2428
Nagel E, Greenwood JP, McCann GP, Bettencourt N, ... Berry C,
N Engl J Med: 19 Jan 2019; 380:2418-2428 | PMID: 31216398
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Abstract

Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer.

Im SA, Lu YS, Bardia A, Harbeck N, ... Hurvitz S, Tripathy D
An earlier analysis of this phase 3 trial showed that the addition of a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor to endocrine therapy provided a greater benefit with regard to progression-free survival than endocrine therapy alone in premenopausal or perimenopausal patients with advanced hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer. Here we report the results of a protocol-specified interim analysis of the key secondary end point of overall survival.

N Engl J Med: 24 Jan 2019; 381:307-316
Im SA, Lu YS, Bardia A, Harbeck N, ... Hurvitz S, Tripathy D
N Engl J Med: 24 Jan 2019; 381:307-316 | PMID: 31166679
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Abstract

Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis.

Mandel-Brehm C, Dubey D, Kryzer TJ, O\'Donovan BD, ... Wilson MR, Pittock SJ
A 37-year-old man with a history of seminoma presented with vertigo, ataxia, and diplopia. An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of programmable phage display. Immunoassays were used to identify KLHL11 IgG in 12 other men with similar neurologic features and testicular disease. Immunostaining of the patient\'s IgG on mouse brain tissue showed sparse but distinctive points of staining in multiple brain regions, with enrichment in perivascular and perimeningeal tissues. The onset of the neurologic syndrome preceded the diagnosis of seminoma in 9 of the 13 patients. An age-adjusted estimate of the prevalence of autoimmune KLHL11 encephalitis in Olmsted County, Minnesota, was 2.79 cases per 100,000 men. (Funded by the Rochester Epidemiology Project and others.).

N Engl J Med: 03 Jan 2019; 381:47-54
Mandel-Brehm C, Dubey D, Kryzer TJ, O'Donovan BD, ... Wilson MR, Pittock SJ
N Engl J Med: 03 Jan 2019; 381:47-54 | PMID: 31269365
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Abstract

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis.

Iversen K, Ihlemann N, Gill SU, Madsen T, ... Moser C, Bundgaard H
Patients with infective endocarditis on the left side of the heart are typically treated with intravenous antibiotic agents for up to 6 weeks. Whether a shift from intravenous to oral antibiotics once the patient is in stable condition would result in efficacy and safety similar to those with continued intravenous treatment is unknown.

N Engl J Med: 30 Jan 2019; 380:415-424
Iversen K, Ihlemann N, Gill SU, Madsen T, ... Moser C, Bundgaard H
N Engl J Med: 30 Jan 2019; 380:415-424 | PMID: 30152252
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Abstract

Intensive Glucose Control in Patients with Type 2 Diabetes - 15-Year Follow-up.

Reaven PD, Emanuele NV, Wiitala WL, Bahn GD, ... Hayward RA,
We previously reported that a median of 5.6 years of intensive as compared with standard glucose lowering in 1791 military veterans with type 2 diabetes resulted in a risk of major cardiovascular events that was significantly lower (by 17%) after a total of 10 years of combined intervention and observational follow-up. We now report the full 15-year follow-up.

N Engl J Med: 05 Jun 2019; 380:2215-2224
Reaven PD, Emanuele NV, Wiitala WL, Bahn GD, ... Hayward RA,
N Engl J Med: 05 Jun 2019; 380:2215-2224 | PMID: 31167051
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Abstract

Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults.

Casey JD, Janz DR, Russell DW, Vonderhaar DJ, ... Semler MW,
Hypoxemia is the most common complication during tracheal intubation of critically ill adults and may increase the risk of cardiac arrest and death. Whether positive-pressure ventilation with a bag-mask device (bag-mask ventilation) during tracheal intubation of critically ill adults prevents hypoxemia without increasing the risk of aspiration remains controversial.

N Engl J Med: 27 Jan 2019; 380:811-821
Casey JD, Janz DR, Russell DW, Vonderhaar DJ, ... Semler MW,
N Engl J Med: 27 Jan 2019; 380:811-821 | PMID: 30779528
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Abstract

Ibrutinib and Venetoclax for First-Line Treatment of CLL.

Jain N, Keating M, Thompson P, Ferrajoli A, ... Gandhi V, Wierda W
Ibrutinib, an inhibitor of Bruton\'s tyrosine kinase, and venetoclax, an inhibitor of B-cell lymphoma 2 protein, have been approved for patients with chronic lymphocytic leukemia (CLL). Preclinical investigations have indicated potential synergistic interaction of their combination.

N Engl J Med: 29 Jan 2019; 380:2095-2103
Jain N, Keating M, Thompson P, Ferrajoli A, ... Gandhi V, Wierda W
N Engl J Med: 29 Jan 2019; 380:2095-2103 | PMID: 31141631
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Abstract

Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients.

Woolley AE, Singh SK, Goldberg HJ, Mallidi HR, ... Baden LR,
Hearts and lungs from donors with hepatitis C viremia are typically not transplanted. The advent of direct-acting antiviral agents to treat hepatitis C virus (HCV) infection has raised the possibility of substantially increasing the donor organ pool by enabling the transplantation of hearts and lungs from HCV-infected donors into recipients who do not have HCV infection.

N Engl J Med: 24 Jan 2019; 380:1606-1617
Woolley AE, Singh SK, Goldberg HJ, Mallidi HR, ... Baden LR,
N Engl J Med: 24 Jan 2019; 380:1606-1617 | PMID: 30946553
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Abstract

Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer.

Fizazi K, Shore N, Tammela TL, Ulys A, ... Smith MR,
Darolutamide is a structurally unique androgen-receptor antagonist that is under development for the treatment of prostate cancer. We evaluated the efficacy of darolutamide for delaying metastasis and death in men with nonmetastatic, castration-resistant prostate cancer.

N Engl J Med: 27 Jan 2019; 380:1235-1246
Fizazi K, Shore N, Tammela TL, Ulys A, ... Smith MR,
N Engl J Med: 27 Jan 2019; 380:1235-1246 | PMID: 30763142
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Abstract

Procedural Volume and Outcomes for Transcatheter Aortic-Valve Replacement.

Vemulapalli S, Carroll JD, Mack MJ, Li Z, ... Brindis RG, Bavaria JE
During the introduction of transcatheter aortic-valve replacement (TAVR) in the United States, requirements regarding procedural volume were mandated by the Centers for Medicare and Medicaid Services as a condition of reimbursement. A better understanding of the relationship between hospital volume of TAVR procedures and patient outcomes could inform policy decisions.

N Engl J Med: 26 Jan 2019; 380:2541-2550
Vemulapalli S, Carroll JD, Mack MJ, Li Z, ... Brindis RG, Bavaria JE
N Engl J Med: 26 Jan 2019; 380:2541-2550 | PMID: 30946551
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Abstract

Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.

Rini BI, Plimack ER, Stus V, Gafanov R, ... Powles T,
The combination of pembrolizumab and axitinib showed antitumor activity in a phase 1b trial involving patients with previously untreated advanced renal-cell carcinoma. Whether pembrolizumab plus axitinib would result in better outcomes than sunitinib in such patients was unclear.

N Engl J Med: 20 Jan 2019; 380:1116-1127
Rini BI, Plimack ER, Stus V, Gafanov R, ... Powles T,
N Engl J Med: 20 Jan 2019; 380:1116-1127 | PMID: 30779529
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Abstract

Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.

Motzer RJ, Penkov K, Haanen J, Rini B, ... di Pietro A, Choueiri TK
In a single-group, phase 1b trial, avelumab plus axitinib resulted in objective responses in patients with advanced renal-cell carcinoma. This phase 3 trial involving previously untreated patients with advanced renal-cell carcinoma compared avelumab plus axitinib with the standard-of-care sunitinib.

N Engl J Med: 20 Jan 2019; 380:1103-1115
Motzer RJ, Penkov K, Haanen J, Rini B, ... di Pietro A, Choueiri TK
N Engl J Med: 20 Jan 2019; 380:1103-1115 | PMID: 30779531
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Abstract

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events.

Ridker PM, Everett BM, Pradhan A, MacFadyen JG, ... Glynn RJ,
Inflammation is causally related to atherothrombosis. Treatment with canakinumab, a monoclonal antibody that inhibits inflammation by neutralizing interleukin-1β, resulted in a lower rate of cardiovascular events than placebo in a previous randomized trial. We sought to determine whether an alternative approach to inflammation inhibition with low-dose methotrexate might provide similar benefit.

N Engl J Med: 20 Jan 2019; 380:752-762
Ridker PM, Everett BM, Pradhan A, MacFadyen JG, ... Glynn RJ,
N Engl J Med: 20 Jan 2019; 380:752-762 | PMID: 30415610
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Abstract

Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria.

Lacerda MVG, Llanos-Cuentas A, Krudsood S, Lon C, ... Green JA, Koh GCKW
Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed \"radical cure\"). Tafenoquine is a single-dose 8-aminoquinoline that has recently been registered for the radical cure of P. vivax.

N Engl J Med: 16 Jan 2019; 380:215-228
Lacerda MVG, Llanos-Cuentas A, Krudsood S, Lon C, ... Green JA, Koh GCKW
N Engl J Med: 16 Jan 2019; 380:215-228 | PMID: 30650322
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Impact:
Abstract

Coronary Arteritis in IgG4-Related Disease.

de la Fuente J, Bird J


N Engl J Med: 29 May 2019; 380:2156
de la Fuente J, Bird J
N Engl J Med: 29 May 2019; 380:2156 | PMID: 31141636
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Effect of Adding Azithromycin to Seasonal Malaria Chemoprevention.

Chandramohan D, Dicko A, Zongo I, Sagara I, ... Ouedraogo JB, Greenwood B
Mass administration of azithromycin for trachoma control led to a sustained reduction in all-cause mortality among Ethiopian children. Whether the addition of azithromycin to the monthly sulfadoxine-pyrimethamine plus amodiaquine used for seasonal malaria chemoprevention could reduce mortality and morbidity among African children was unclear.

N Engl J Med: 05 Jan 2019; 380:2197-2206
Chandramohan D, Dicko A, Zongo I, Sagara I, ... Ouedraogo JB, Greenwood B
N Engl J Med: 05 Jan 2019; 380:2197-2206 | PMID: 30699301
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Omadacycline for Acute Bacterial Skin and Skin-Structure Infections.

O\'Riordan W, Green S, Overcash JS, Puljiz I, ... Steenbergen JN, Loh E
Acute bacterial skin and skin-structure infections are associated with substantial morbidity and health care costs. Omadacycline, an aminomethylcycline antibiotic that can be administered once daily either orally or intravenously, is active against pathogens that commonly cause such infections, including antibiotic-resistant strains.

N Engl J Med: 06 Jan 2019; 380:528-538
O'Riordan W, Green S, Overcash JS, Puljiz I, ... Steenbergen JN, Loh E
N Engl J Med: 06 Jan 2019; 380:528-538 | PMID: 30726689
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Case 21-2019: A 31-Year-Old Woman with Vision Loss.

Matiello M, Juliano AF, Bowley M, Karaa A


N Engl J Med: 10 Jul 2019; 381:164-172
Matiello M, Juliano AF, Bowley M, Karaa A
N Engl J Med: 10 Jul 2019; 381:164-172 | PMID: 31291520
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Case 20-2019: A 52-Year-Old Woman with Fever and Rash after Heart Transplantation.

Ison MG, Lebeis TA, Barros N, Lewis GD, Massoth LR


N Engl J Med: 26 Jun 2019; 380:2564-2573
Ison MG, Lebeis TA, Barros N, Lewis GD, Massoth LR
N Engl J Med: 26 Jun 2019; 380:2564-2573 | PMID: 31242366
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Nonbacterial Thrombotic Endocarditis.

Fournier JB, Testa EJ


N Engl J Med: 19 Jun 2019; 380:e48
Fournier JB, Testa EJ
N Engl J Med: 19 Jun 2019; 380:e48 | PMID: 31216402
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Situs Inversus Totalis.

Gentile BA, Tighe DA


N Engl J Med: 12 Jun 2019; 380:e45
Gentile BA, Tighe DA
N Engl J Med: 12 Jun 2019; 380:e45 | PMID: 31189040
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Cytoplasmic Blebs in T-Cell Prolymphocytic Leukemia.

Abbas HA, Han X


N Engl J Med: 12 Jun 2019; 380:2360
Abbas HA, Han X
N Engl J Med: 12 Jun 2019; 380:2360 | PMID: 31189039
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

A Disturbing Decline.

Braun DA, Henderson GV, Sax PE, Miller AL, Loscalzo J


N Engl J Med: 05 Jun 2019; 380:2257-2262
Braun DA, Henderson GV, Sax PE, Miller AL, Loscalzo J
N Engl J Med: 05 Jun 2019; 380:2257-2262 | PMID: 31167056
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Chronic Silicosis with Progressive Massive Fibrosis.

Riley L, Urbine D


N Engl J Med: 05 Jun 2019; 380:2256
Riley L, Urbine D
N Engl J Med: 05 Jun 2019; 380:2256 | PMID: 31167054
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Clinical and Therapeutic Implications of Cancer Stem Cells.

Clarke MF


N Engl J Med: 05 Jun 2019; 380:2237-2245
Clarke MF
N Engl J Med: 05 Jun 2019; 380:2237-2245 | PMID: 31167052
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Case 17-2019: A 44-Year-Old Man with Joint Pain, Weight Loss, and Chest Pain.

Arvikar SL, Schoenfeld SR, Fox AS, Tanguturi VK, Stuart LD


N Engl J Med: 29 May 2019; 380:2157-2167
Arvikar SL, Schoenfeld SR, Fox AS, Tanguturi VK, Stuart LD
N Engl J Med: 29 May 2019; 380:2157-2167 | PMID: 31141639
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Infection.

Hogan CA, Schwenk H


N Engl J Med: 22 May 2019; 380:e39
Hogan CA, Schwenk H
N Engl J Med: 22 May 2019; 380:e39 | PMID: 31116922
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Question-Mark Appearance of the Colon.

Masiakos PT, Wales PW


N Engl J Med: 22 May 2019; 380:2051
Masiakos PT, Wales PW
N Engl J Med: 22 May 2019; 380:2051 | PMID: 31116921
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Case 15-2019: A 55-Year-Old Man with Jaundice.

Schaefer EA, Anderson MA, Kim AY, Sfeir MM


N Engl J Med: 15 May 2019; 380:1955-1963
Schaefer EA, Anderson MA, Kim AY, Sfeir MM
N Engl J Med: 15 May 2019; 380:1955-1963 | PMID: 31091378
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Tornwaldt\'s Cyst.

Huang CY, Kang BH


N Engl J Med: 15 May 2019; 380:e37
Huang CY, Kang BH
N Engl J Med: 15 May 2019; 380:e37 | PMID: 31091377
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Liver Involvement in Autosomal Dominant Polycystic Kidney Disease.

Adin ME


N Engl J Med: 15 May 2019; 380:1954
Adin ME
N Engl J Med: 15 May 2019; 380:1954 | PMID: 31091376
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

The Power and Limits of Classification - A 32-Year-Old Man with Abdominal Pain.

Stroumsa D, Roberts EFS, Kinnear H, Harris LH


N Engl J Med: 15 May 2019; 380:1885-1888
Stroumsa D, Roberts EFS, Kinnear H, Harris LH
N Engl J Med: 15 May 2019; 380:1885-1888 | PMID: 31091369
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Case 14-2019: A 44-Year-Old Man with Neck Pain and Swelling.

Saylor PJ, Dudzinski DM, Mendoza DP, Glomski K


N Engl J Med: 08 May 2019; 380:1854-1863
Saylor PJ, Dudzinski DM, Mendoza DP, Glomski K
N Engl J Med: 08 May 2019; 380:1854-1863 | PMID: 31067377
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Metastatic Uveal Melanoma.

Everett L, Copperman T


N Engl J Med: 08 May 2019; 380:1853
Everett L, Copperman T
N Engl J Med: 08 May 2019; 380:1853 | PMID: 31067375
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Cutis Verticis Gyrata Associated with Acromegaly.

Parolin M, Dassie F


N Engl J Med: 01 May 2019; 380:e31
Parolin M, Dassie F
N Engl J Med: 01 May 2019; 380:e31 | PMID: 31042829
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Tick Attached to the Tympanic Membrane.

Kasle D, Waldman E


N Engl J Med: 01 May 2019; 380:1761
Kasle D, Waldman E
N Engl J Med: 01 May 2019; 380:1761 | PMID: 31042828
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Case 13-2019: A 54-Year-Old Man with Alcohol Withdrawal and Altered Mental Status.

Fenves AZ, Mojtahed A, Nisavic M, Massoth LR


N Engl J Med: 24 Apr 2019; 380:1657-1665
Fenves AZ, Mojtahed A, Nisavic M, Massoth LR
N Engl J Med: 24 Apr 2019; 380:1657-1665 | PMID: 31018073
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Hydroxychloroquine Retinal Toxicity.

Proano C, Kimball GP


N Engl J Med: 24 Apr 2019; 380:e27
Proano C, Kimball GP
N Engl J Med: 24 Apr 2019; 380:e27 | PMID: 31018072
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Bull\'s-Eye Maculopathy Associated with Hydroxychloroquine.

Modi YS, Singh RP


N Engl J Med: 24 Apr 2019; 380:1656
Modi YS, Singh RP
N Engl J Med: 24 Apr 2019; 380:1656 | PMID: 31018071
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Case 12-2019: A 60-Year-Old Man with Weakness and Difficulty Chewing.

Doughty CT, Guidon AC, Paganoni S, Hedley-Whyte ET


N Engl J Med: 17 Apr 2019; 380:1566-1574
Doughty CT, Guidon AC, Paganoni S, Hedley-Whyte ET
N Engl J Med: 17 Apr 2019; 380:1566-1574 | PMID: 30995378
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Thrombotic Thrombocytopenic Purpura.

Bhandari S, Kumar R


N Engl J Med: 17 Apr 2019; 380:e23
Bhandari S, Kumar R
N Engl J Med: 17 Apr 2019; 380:e23 | PMID: 30995377
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer.

Mariette C, Markar SR, Dabakuyo-Yonli TS, Meunier B, ... Piessen G,
Postoperative complications, especially pulmonary complications, affect more than half the patients who undergo open esophagectomy for esophageal cancer. Whether hybrid minimally invasive esophagectomy results in lower morbidity than open esophagectomy is unclear.

N Engl J Med: 09 Jan 2019; 380:152-162
Mariette C, Markar SR, Dabakuyo-Yonli TS, Meunier B, ... Piessen G,
N Engl J Med: 09 Jan 2019; 380:152-162 | PMID: 30625052
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa.

Tshilolo L, Tomlinson G, Williams TN, Santos B, ... Ware RE,
Hydroxyurea is an effective treatment for sickle cell anemia, but few studies have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting conditions such as malnutrition and malaria may affect the feasibility, safety, and benefits of hydroxyurea in low-resource settings.

N Engl J Med: 09 Jan 2019; 380:121-131
Tshilolo L, Tomlinson G, Williams TN, Santos B, ... Ware RE,
N Engl J Med: 09 Jan 2019; 380:121-131 | PMID: 30501550
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria.

Sardh E, Harper P, Balwani M, Stein P, ... Simon AR, Anderson KE
Induction of delta aminolevulinic acid synthase 1 ( ALAS1) gene expression and accumulation of neurotoxic intermediates result in neurovisceral attacks and disease manifestations in patients with acute intermittent porphyria, a rare inherited disease of heme biosynthesis. Givosiran is an investigational RNA interference therapeutic agent that inhibits hepatic ALAS1 synthesis.

N Engl J Med: 06 Jan 2019; 380:549-558
Sardh E, Harper P, Balwani M, Stein P, ... Simon AR, Anderson KE
N Engl J Med: 06 Jan 2019; 380:549-558 | PMID: 30726693
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Omadacycline for Community-Acquired Bacterial Pneumonia.

Stets R, Popescu M, Gonong JR, Mitha I, ... McGovern PC, Loh E
Omadacycline, a new once-daily aminomethylcycline antibiotic agent that can be administered intravenously or orally, reaches high concentrations in pulmonary tissues and is active against common pathogens that cause community-acquired bacterial pneumonia.

N Engl J Med: 06 Jan 2019; 380:517-527
Stets R, Popescu M, Gonong JR, Mitha I, ... McGovern PC, Loh E
N Engl J Med: 06 Jan 2019; 380:517-527 | PMID: 30726692
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Angiotensin-Neprilysin Inhibition in Acute Decompensated Heart Failure.

Velazquez EJ, Morrow DA, DeVore AD, Duffy CI, ... Braunwald E,
Acute decompensated heart failure accounts for more than 1 million hospitalizations in the United States annually. Whether the initiation of sacubitril-valsartan therapy is safe and effective among patients who are hospitalized for acute decompensated heart failure is unknown.

N Engl J Med: 06 Jan 2019; 380:539-548
Velazquez EJ, Morrow DA, DeVore AD, Duffy CI, ... Braunwald E,
N Engl J Med: 06 Jan 2019; 380:539-548 | PMID: 30415601
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Colovesical Fistula.

Ashrafi AN, Sotelo R


N Engl J Med: 26 Jun 2019; 380:e51
Ashrafi AN, Sotelo R
N Engl J Med: 26 Jun 2019; 380:e51 | PMID: 31242365
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Case 18-2019: A 24-Year-Old Woman with a Pelvic Mass.

Spriggs DR, Melamed A, Li W, Safdar N


N Engl J Med: 12 Jun 2019; 380:2361-2369
Spriggs DR, Melamed A, Li W, Safdar N
N Engl J Med: 12 Jun 2019; 380:2361-2369 | PMID: 31189041
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma.

Schuster SJ, Bishop MR, Tam CS, Waller EK, ... Maziarz RT,
Patients with diffuse large B-cell lymphoma that is refractory to primary and second-line therapies or that has relapsed after stem-cell transplantation have a poor prognosis. The chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel targets and eliminates CD19-expressing B cells and showed efficacy against B-cell lymphomas in a single-center, phase 2a study.

N Engl J Med: 02 Jan 2019; 380:45-56
Schuster SJ, Bishop MR, Tam CS, Waller EK, ... Maziarz RT,
N Engl J Med: 02 Jan 2019; 380:45-56 | PMID: 30501490
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer.

Manson JE, Cook NR, Lee IM, Christen W, ... Buring JE,
Higher intake of marine n-3 (also called omega-3) fatty acids has been associated with reduced risks of cardiovascular disease and cancer in several observational studies. Whether supplementation with n-3 fatty acids has such effects in general populations at usual risk for these end points is unclear.

N Engl J Med: 02 Jan 2019; 380:23-32
Manson JE, Cook NR, Lee IM, Christen W, ... Buring JE,
N Engl J Med: 02 Jan 2019; 380:23-32 | PMID: 30415637
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

A Disturbing Decline.

Braun DA, Simchowitz B, Henderson GV, Sax PE, Vaidya A


N Engl J Med: 29 May 2019; 380:e42
Braun DA, Simchowitz B, Henderson GV, Sax PE, Vaidya A
N Engl J Med: 29 May 2019; 380:e42 | PMID: 31141638
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

A STEMI Mimic.

Yu D, Blair JEA


N Engl J Med: 29 May 2019; 380:e41
Yu D, Blair JEA
N Engl J Med: 29 May 2019; 380:e41 | PMID: 31141637
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Case 16-2019: A 53-Year-Old Man with Cough and Eosinophilia.

Simmons RP, Dudzinski DM, Shepard JO, Hurtado RM, Coffey KC


N Engl J Med: 22 May 2019; 380:2052-2059
Simmons RP, Dudzinski DM, Shepard JO, Hurtado RM, Coffey KC
N Engl J Med: 22 May 2019; 380:2052-2059 | PMID: 31116923
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Whooping Cough in a Young Infant.

Hillier D


N Engl J Med: 10 Jul 2019; 381:e4
Hillier D
N Engl J Med: 10 Jul 2019; 381:e4 | PMID: 31291519
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

\"Double Tongue\" Appearance in Ludwig\'s Angina.

Mohamad I, Narayanan MS


N Engl J Med: 10 Jul 2019; 381:163
Mohamad I, Narayanan MS
N Engl J Med: 10 Jul 2019; 381:163 | PMID: 31291518
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Weak and Winded.

Lee I, Walker JB, Nozaki K, Willett LL


N Engl J Med: 03 Jul 2019; 381:76-82
Lee I, Walker JB, Nozaki K, Willett LL
N Engl J Med: 03 Jul 2019; 381:76-82 | PMID: 31269370
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

(Pinworm) Infection.

Kang WH, Jee SC


N Engl J Med: 03 Jul 2019; 381:e1
Kang WH, Jee SC
N Engl J Med: 03 Jul 2019; 381:e1 | PMID: 31269369
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Pneumoperitoneum from a Gastric Perforation.

Masson A, Cheron G


N Engl J Med: 03 Jul 2019; 381:75
Masson A, Cheron G
N Engl J Med: 03 Jul 2019; 381:75 | PMID: 31269368
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Chronic Rhinosinusitis with Nasal Polyps.

Hopkins C


N Engl J Med: 03 Jul 2019; 381:55-63
Hopkins C
N Engl J Med: 03 Jul 2019; 381:55-63 | PMID: 31269366
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Thyroglossal Duct Cyst.

Tanitame K, Konishi H


N Engl J Med: 26 Jun 2019; 380:2563
Tanitame K, Konishi H
N Engl J Med: 26 Jun 2019; 380:2563 | PMID: 31242364
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Case 19-2019: A 38-Year-Old Woman with Abdominal Pain and Fever.

Khalili H, O\'Shea A, Robbins GK, Zukerberg LR


N Engl J Med: 19 Jun 2019; 380:2461-2470
Khalili H, O'Shea A, Robbins GK, Zukerberg LR
N Engl J Med: 19 Jun 2019; 380:2461-2470 | PMID: 31216403
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Injury from E-Cigarette Explosion.

Katz MG, Russell KW


N Engl J Med: 19 Jun 2019; 380:2460
Katz MG, Russell KW
N Engl J Med: 19 Jun 2019; 380:2460 | PMID: 31216401
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Heatstroke.

Epstein Y, Yanovich R


N Engl J Med: 19 Jun 2019; 380:2449-2459
Epstein Y, Yanovich R
N Engl J Med: 19 Jun 2019; 380:2449-2459 | PMID: 31216400
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Nonnarcotic Methods of Pain Management.

Finnerup NB


N Engl J Med: 19 Jun 2019; 380:2440-2448
Finnerup NB
N Engl J Med: 19 Jun 2019; 380:2440-2448 | PMID: 31216399
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Disseminated Coccidioidomycosis.

Myers RA, Zmarlicka MT


N Engl J Med: 05 Jun 2019; 380:e44
Myers RA, Zmarlicka MT
N Engl J Med: 05 Jun 2019; 380:e44 | PMID: 31167055
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Disseminated Gonococcal Infection.

Florez-Pollack S, Mauskar MM


N Engl J Med: 17 Apr 2019; 380:1565
Florez-Pollack S, Mauskar MM
N Engl J Med: 17 Apr 2019; 380:1565 | PMID: 30995376
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Case 11-2019: A 49-Year-Old Man with HIV Infection and Chronic Kidney Disease.

Wojciechowski D, Gandhi RT, Rosales IA


N Engl J Med: 10 Apr 2019; 380:1464-1472
Wojciechowski D, Gandhi RT, Rosales IA
N Engl J Med: 10 Apr 2019; 380:1464-1472 | PMID: 30970193
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Diffuse Subcutaneous Emphysema.

St Clair TM, Zwemer E


N Engl J Med: 10 Apr 2019; 380:e20
St Clair TM, Zwemer E
N Engl J Med: 10 Apr 2019; 380:e20 | PMID: 30970192
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Traumatic Iridodialysis.

Hsiao CC, Chen WL


N Engl J Med: 10 Apr 2019; 380:1463
Hsiao CC, Chen WL
N Engl J Med: 10 Apr 2019; 380:1463 | PMID: 30970191
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
Abstract

Sepsis Guidelines.

Chen AX, Simpson SQ, Pallin DJ


N Engl J Med: 03 Apr 2019; 380:1369-1371
Chen AX, Simpson SQ, Pallin DJ
N Engl J Med: 03 Apr 2019; 380:1369-1371 | PMID: 30943343
Go to: DOI | PubMed | PDF | Google Scholar |
Impact:
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