Journal: J Nucl Cardiol

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Abstract

Anthropomorphic cardiac phantom for dynamic SPECT.

Krakovich A, Zaretsky U, Gelbart E, Moalem I, ... Scheinowitz M, Goldkorn R
Background
As myocardial blood flow measurement (MBF) in SPECT systems became recently available, significant effort has been devoted to its validation. For that purpose, we have developed a cardiac phantom that is able to mimic physiological radiotracer variation in the left ventricle cavity and in the myocardium, while performing beating-like motion. The new phantom is integrated inside a standard anthropomorphic torso allowing a realistic tissue attenuation and gamma-ray scattering METHODS AND
Results:
A mechanical cardiac phantom was integrated in a commercially available anthropomorphic torso. Using a GE Discovery 530c SPECT, measurements were performed. It was found that gamma-ray attenuation effects are significant and limit the MBF measurements to global/three-vessel resolution. Dynamic SPECT experiments were performed to validate MBF accuracy and showed mean relative error of 14%. Finally, the effect of varying radiotracer dose on the accuracy of dynamic SPECT was studied
Conclusions:
A dynamic cardiac phantom has been developed and successfully integrated in a standard SPECT torso. A good agreement was found between SPECT-reported MBF values and the expected results. Despite increased noise-to-signal ratio when radiotracer doses were reduced, MBF uncertainty did not increase significantly down to very low doses, thanks to the temporal integration of the activity during the measurement.

© 2022. The Author(s) under exclusive licence to American Society of Nuclear Cardiology.

J Nucl Cardiol: 27 Jun 2022; epub ahead of print
Krakovich A, Zaretsky U, Gelbart E, Moalem I, ... Scheinowitz M, Goldkorn R
J Nucl Cardiol: 27 Jun 2022; epub ahead of print | PMID: 35760983
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This program is still in alpha version.