Time Trend in Incidence of Sudden Cardiac Death After Percutaneous Coronary Intervention from 2009 to 2017 (from the Japanese Multicenter Registry)
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Section snippets
Methods
This study was conducted as part of the Japan Cardiovascular Database-Keio Interhospital Cardiovascular Studies (JCD-KiCS) PCI registry. This is a multicenter, prospective registry that includes data of consecutive patients who underwent PCI between 2009 and 2017 at 15 institutions within the Tokyo metropolitan area. It includes primarily large tertiary care referral centers (≥200 beds; n = 13) and a few midsized satellite hospitals (<200 beds; n = 2). The details of this registry have been
Results
The baseline characteristics of the patients (n = 8,723) are summarized in Table 1. The patients’ baseline characteristics changed between 2009 and 2017 (Table 1). The prevalence of old MI (p for trend <0.001) and HF decreased (p for trend = 0.027), whereas mean LVEF and age increased (p for trend <0.001 for both). Furthermore, the principal indication for PCI shifted from ACS to stable CAD. Regarding medications at discharge, there was a temporal increase in statins and P2Y12 inhibitors (all p
Discussion
In this study, we observed the following: (1) the 2-year crude incidence of SCD after PCI was approximately 0.4% and decreased during the study period, (2) the proportion of the second-generation DES implantation increased after the approval for its use, (3) the incidence of SCD was almost similar between patients with ACS and those with stable CAD, whereas SCDs occurred more frequently immediately after PCI in those with ACS, and (4) the HF and prescription of statins were associated with
Disclosures
Dr Kohsaka reports investigator-initiated grant funding from Bayer and Daiichi Sankyo. The remaining authors have no conflicts of interest to declare. Dr. Ikemura received an unrestricted research grant for the Department of Cardiology, Keio University School of Medicine from Bristol Myer Squibb.
Acknowledgment
The authors would like to thank the members of the cardiac catheterization laboratories of the participating institutions and the clinical research coordinators involved in the JCD-KiCS study. The English language editing (Editage, https://www.editage.jp) in this study was supported by a Grant-in-Aid for Scientific Research (Japan Society for the Promotion of Science KAKENHI; 22K16067).
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Funding: The present study was funded by the Grants-in-Aid for Scientific Research KAKENHI; Nos. 20H03915 from the Japan Society for the Promotion of Science.