Effect of Implanted Defibrillator on Mortality in Patients With Chronic Kidney Disease
Section snippets
Methods
There was a preplanned protocol for systematic review and results were reported per Preferred Reporting Items for Systematic Reviews and Meta-Analyses.6 There was an electronic search performed of the following databases: EBSCO CINAHL, Google Scholar, Ovid Embase, MEDLINE, and Web of Science. References of selected studies, along with other publications from the first and corresponding authors, were searched and included. The following Medical Subject Headings terms used for search: CKD, kidney
Results
Using the previously described search term criteria, the initial search yielded 834 studies. Of these, only 18 studies were included for full-text screening after excluding case reports, review articles, and editorials. Ultimately, 14 studies with 70,661 patients met the criteria and were included in the analysis (Figure 1). We included both observational and randomized trials. We included all patients with ICD alone or with resynchronization therapy.
The study population included 70,661
Discussion
The major finding of our study is that ICD implantation in patients with CKD was associated with a significant reduction in long-term all-cause mortality. This long-term mortality benefit was particularly evident in patients with CKD who were not on dialysis, but a similar trend was observed in patients who underwent dialysis.
CKD is an inflammatory condition and has been shown to cause myocardial inflammation, rendering the ventricular myocardium more arrhythmogenic.20 Moreover, this chronic
Authors Contributions
Conceptualization: Mohammed Al-Sadawi; Data curation: Mohammed Al-Sadawi and Hina Ijaz; Formal analysis: Mohammed Al-Sadawi and Mahmoud Alsaiqali; Funding acquisition: none; Investigation: roger Fan and Eric Rashba; Methodology: Faisal Aslam; Project administration: Eric Rashba; Resources: Faisal Aslam; Software: Faisal Aslam; Supervision: roger Fan and Eric Rashba; Validation: Mohammed Al-Sadawi and Faisal Aslam; Visualization: Mohammed Al-Sadawi and Faisal Aslam; Roles/Writing - original
Disclosures
The authors have no conflicts of interest to declare.
Guidelines statement
The systematic review was conducted with a protocol in accordance with the Preferred Reporting of Items for Systematic reviews and Meta-Analyses statement.
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Funding: none.