Apical aneurysm formation in apical hypertrophic cardiomyopathy: Pilot study with cardiac magnetic resonance

Int J Cardiol. 2023 Jan 15:371:480-485. doi: 10.1016/j.ijcard.2022.09.024. Epub 2022 Sep 15.

Abstract

Background: The dynamic changes and apical aneurysm formation in apical hypertrophic cardiomyopathy (HCM) have not been specifically described. This study aimed to describe these changes to better understand the progression of apical HCM.

Methods and results: Seventy-two patients with apical HCM who underwent at least two cardiac magnetic resonance (CMR) examinations were retrospectively included in this study. The mean interval between the first and last CMR examinations was 50.1 ± 26.8 months (ranging from 4 to 118 months). Compared with the initial values, the left atrial diameter, maximum left ventricular wall thickness and late gadolinium enhancement extent significantly increased (all P < 0.05), while the left ventricular ejection fraction significantly decreased (P < 0.05), at the latest CMR examination. More importantly, the dynamic process of apical aneurysm formation in apical HCM was observed in a subset of patients, which may follow these four stages: starting with systolic apical cavity obliteration, then broadening of the apical slit in systole, further developing into an apical outpouching, and finally forming an apical aneurysm. Eleven patients experienced adverse cardiovascular events, including new-onset or progressive atrial fibrillation (n = 7), hospitalization with heart failure (n = 3) and implantable cardioverter defibrillator intervention (n = 1), at the time of the latest CMR examination.

Conclusions: In the progression of apical HCM, cardiac structure and function will change accordingly. Apical aneurysm formation in apical HCM is a chronic and continuous dynamic process that may follow a 4-step pathway of disease progression.

Keywords: Aneurysm; Apical hypertrophic cardiomyopathy; Atrial fibrillation; Cardiac magnetic resonance; Outpouching.

MeSH terms

  • Aneurysm*
  • Apical Hypertrophic Cardiomyopathy*
  • Cardiomyopathy, Hypertrophic*
  • Contrast Media
  • Gadolinium
  • Humans
  • Magnetic Resonance Spectroscopy
  • Pilot Projects
  • Retrospective Studies
  • Stroke Volume
  • Ventricular Function, Left

Substances

  • Gadolinium
  • Contrast Media