Comparative Prognostic Value of Parameters of Pulsatile Right Ventricular Afterload in Patients With Advanced Heart Failure Awaiting Heart Transplantation
Section snippets
Methods
This was an observational and retrospective analysis including patients who underwent right-sided cardiac catheterization at Verona University Hospital, during the evaluation for HT between April 2007 and May 2021. The cohort of patients were followed up from the day of right-sided cardiac catheterization until death or any censoring events, including HT, LV assist device (LVAD) implantation, or new hospitalizations for acute heart failure. The inclusion criteria were patients aged older than
Results
Between April 2007 and May 2021, a total of 181 patients with advanced heart failure and left ventricle dysfunction were enlisted for HT at the Department of Cardio-thoracic Surgery of Verona. Complete dataset, including right-sided cardiac catheterization, echocardiographic data, and clinical follow-up, were available for 149 patients who were include this analysis (Figure 1).
The baseline characteristics of study cohort are shown in Table 1. The mean age was 56.6 ± 10.1 years and 85% were men.
Discussion
The main results of our analysis are as follows: (1) determinants of pulsatile RV afterload are strongly associated with adverse outcome in patients with end-stage HFrEF awaiting HT. (2) In particular, PAC but not mPAP demonstrated to be independently associated with the composite end point. (3) PAC provided superior prognostic performance compared with conventional parameters, including cardiac index and PVR.
RV function is an important prognostic determinant in patients with advanced HFrEF.16
Disclosures
The authors have no conflicts of interest to declare.
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