Effects of percutaneous coronary intervention on dyspnea in stable coronary artery disease

Clin Res Cardiol. 2023 Sep;112(9):1194-1203. doi: 10.1007/s00392-022-02107-x. Epub 2022 Sep 13.

Abstract

Background: Dyspnea is a frequent symptom in patients with stable coronary artery disease (CAD) and is recognized as a possible angina equivalent.

Objectives: This study was to assess the impact of percutaneous coronary intervention (PCI) on dyspnea, quality of life, and angina pectoris in patients with stable CAD.

Methods: The prospective, multi-center PLA-pCi-EBO-pilot trial included 144 patients with symptomatic stable CAD and successful PCI. The prespecified endpoints angina pectoris (Seattle Angina Questionnaire-SAQ) and dyspnea (NYHA scale) were assessed 6 months after PCI. Predictors for symptomatic improvement were assessed with uni- and multivariable logistic regression analyses.

Results: Patients with concomitant dyspnea had worse SAQ physical limitation scores at baseline (49.5 ± 21.0 vs 58.9 ± 22.0, p = 0.013) but showed no difference for angina frequency or quality of life. Overall, symptomatic burden of angina pectoris and dyspnea was alleviated by PCI. However, patients with concomitant dyspnea had markedly worse scores for physical limitation (78.9 ± 25.0 vs 94.3 ± 10.6, p < 0.001), angina frequency (77.9 ± 22.8 vs 91.1 ± 12.4, p < 0.001), and quality of life (69.4 ± 24.1 vs 82.5 ± 14.4, p < 0.001) after PCI. The prevalence of dyspnea (NYHA class ≥ 2) declined from 73% before PCI to 54%. Of 95 initially dyspneic patients, 57 (60%) improved at least one NYHA class 6 months after PCI. In a multivariable logistic regression analysis, "atypical angina pectoris" was associated with improved NYHA class, whereas "diabetes mellitus" had a negative association.

Conclusion: PCI effectively reduced dyspnea, which is a frequent and demanding symptom in patients with CAD. The German Clinical Trials Register registration number is DRKS0001752 ( www.drks.de ).

Keywords: Dyspnea; PCI; PLA-pCi-EBO; QoL; Stable CAD.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Angina Pectoris / diagnosis
  • Angina Pectoris / epidemiology
  • Angina Pectoris / therapy
  • Coronary Artery Disease* / complications
  • Coronary Artery Disease* / diagnosis
  • Coronary Artery Disease* / surgery
  • Dyspnea / diagnosis
  • Dyspnea / etiology
  • Health Status
  • Humans
  • Percutaneous Coronary Intervention* / adverse effects
  • Prospective Studies
  • Quality of Life
  • Treatment Outcome