In ischemic stroke, IV alteplase within 3 h of onset improves functional outcome vs. control

Ann Intern Med. 2022 Sep;175(9):JC107. doi: 10.7326/J22-0069. Epub 2022 Sep 6.

Abstract

Mun KT, Bonomo JB, Liebeskind DS, et al. Fragility index meta-analysis of randomized controlled trials shows highly robust evidential strength for benefit of < 3 hour intravenous alteplase. Stroke. 2022;53:2069-74. 35543129.

Publication types

  • Meta-Analysis
  • Comment

MeSH terms

  • Brain Ischemia* / drug therapy
  • Fibrinolytic Agents / therapeutic use
  • Humans
  • Ischemic Stroke*
  • Stroke* / drug therapy
  • Tissue Plasminogen Activator / therapeutic use
  • Treatment Outcome

Substances

  • Fibrinolytic Agents
  • Tissue Plasminogen Activator