Deep-learning-based methods of attenuation correction for SPECT and PET

Attenuation correction (AC) is essential for quantitative analysis and clinical diagnosis of single-photon emission computed tomography (SPECT) and positron emission tomography (PET). In clinical practice, computed tomography (CT) is utilized to generate attenuation maps (μ-maps) for AC of hybrid SPECT/CT and PET/CT scanners. However, CT-based AC methods frequently produce artifacts due to CT artifacts and misregistration of SPECT-CT and PET-CT scans. Segmentation-based AC methods using magnetic resonance imaging (MRI) for PET/MRI scanners are inaccurate and complicated since MRI does not contain direct information of photon attenuation. Computational AC methods for SPECT and PET estimate attenuation coefficients directly from raw emission data, but suffer from low accuracy, cross-talk artifacts, high computational complexity, and high noise level. The recently evolving deep-learning-based methods have shown promising results in AC of SPECT and PET, which can be generally divided into two categories: indirect and direct strategies. Indirect AC strategies apply neural networks to transform emission, transmission, or MR images into synthetic μ-maps or CT images which are then incorporated into AC reconstruction. Direct AC strategies skip the intermediate steps of generating μ-maps or CT images and predict AC SPECT or PET images from non-attenuation-correction (NAC) SPECT or PET images directly. These deep-learning-based AC methods show comparable and even superior performance to non-deep-learning methods. In this article, we first discussed the principles and limitations of non-deep-learning AC methods, and then reviewed the status and prospects of deep-learning-based methods for AC of SPECT and PET.