In overweight or obesity without diabetes, weekly semaglutide vs. daily liraglutide increased weight loss at 68 wk

Ann Intern Med. 2022 May;175(5):JC56. doi: 10.7326/J22-0023. Epub 2022 May 3.

Abstract

Rubino DM, Greenway FL, Khalid U, et al. Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults with overweight or obesity without diabetes: the STEP 8 randomized clinical trial. JAMA. 2022;327:138-50. 35015037.

Publication types

  • Randomized Controlled Trial
  • Comment

MeSH terms

  • Adult
  • Diabetes Mellitus*
  • Diabetes Mellitus, Type 2* / drug therapy
  • Double-Blind Method
  • Glucagon-Like Peptides
  • Humans
  • Hypoglycemic Agents / adverse effects
  • Injections, Subcutaneous
  • Liraglutide / adverse effects
  • Obesity / complications
  • Obesity / drug therapy
  • Overweight / complications
  • Weight Gain
  • Weight Loss

Substances

  • Hypoglycemic Agents
  • semaglutide
  • Glucagon-Like Peptides
  • Liraglutide