Prostaglandin D2 signaling and cardiovascular homeostasis

J Mol Cell Cardiol. 2022 Jun:167:97-105. doi: 10.1016/j.yjmcc.2022.03.011. Epub 2022 Apr 1.

Abstract

Cardiovascular diseases are the leading cause of death worldwide. A chronic inflammatory response is a common pathological alteration in diverse cardiovascular diseases. Prostaglandin (PG) D2, a key lipid mediator derived from arachidonic acid metabolism, promotes resolution of inflammation and regulated T cell function through its receptors. Accumulated evidence has shown that dysregulated PGD2 signaling is involved in the pathogenesis of cardiovascular diseases, including atherosclerosis, hypertension, pulmonary hypertension, abdominal aortic aneurysm, and myocardial ischemia. Here, we summarized the recent progresses on PGD2 in cardiovascular homeostasis and discussed potential therapeutic translation by targeting PGD2 signaling.

Keywords: Atherosclerosis; Chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes; Hypertension; Prostaglandin D(2); Prostaglandin D(2) receptor subtype 1.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cardiovascular Diseases*
  • Homeostasis
  • Humans
  • Inflammation
  • Prostaglandin D2 / metabolism
  • Prostaglandins
  • Receptors, Immunologic / metabolism
  • Receptors, Prostaglandin* / metabolism

Substances

  • Prostaglandins
  • Receptors, Immunologic
  • Receptors, Prostaglandin
  • Prostaglandin D2