Clinical InvestigationsNormal Values for Global Left Ventricular Myocardial WorkNormal Ranges of Global Left Ventricular Myocardial Work Indices in Adults: A Meta-Analysis
Section snippets
Search Strategy
Our systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline.10 Four databases (Embase, PubMed, Scopus, and the Cochrane Library) were systematically searched for the key terms “myocardial work,” “global constructive work,” “global wasted work,” “global work index,” and “global work efficiency” by two coauthors (V.T.T. and H.P.) under the guidance of a librarian trained in performing systematic reviews;
Study Selection
A total of 1,174 titles were located using the search strategy from four databases (PubMed, n = 390; Scopus, n = 390; Embase, n = 362; Cochrane, n = 32; Figure 2). After excluding duplicates (n = 698), 476 articles were screened for relevance. We further excluded articles unrelated to the topic or abstracts without text, reviews, articles not in English, and studies not in humans. Additionally, searching the bibliographies did not reveal any additional studies. Only 13 studies with 1,665
Discussion
To the best of our knowledge, this is the first meta-analysis to provide pooled estimates for echocardiographic values of noninvasive global MW (GMW) among healthy subjects. In establishing reference ranges and the potential impacts of potential confounders on GMW values, our study provides a framework for future comparison of study groups to normal control subjects.
LVEF has become a cornerstone in contemporary clinical practice, guiding patient management and prognosis in a variety of clinical
Conclusion
In this meta-analysis, we provide echocardiographic reference ranges for noninvasive indices of MW. These normal values could served as a reference for clinical and research use.
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Cited by (21)
Myocardial Work as a Metric of Cardiac Performance
2023, Journal of the American Society of EchocardiographyState-of-the-Art: Noninvasive Assessment of Left Ventricular Function Through Myocardial Work
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2023, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :Second, the authors assessed the mean or median values ± SD or IQR, as appropriate, prebypass at timepoint T1 by TEE for GWI and GCW of 1,224 ± 312 mmHg% and 1,460 ± 312 mmHg%, respectively, and observed mean values of 143 mmHg% (IQR 99-183) for GWW and 89% (IQR 85-92) for GWE. Compared to published TTE-assessed reference values of healthy, awake, and spontaneously breathing individuals from the NORRE study33 and a recent meta-analysis from Truong et al.,34 the pre-bypass values assessed by TEE in the authors’ patient population here seemed to be reduced. Manganaro et al.33 reported mean values of 1,896 ± 308 mmHg% for GWI, 2,232 ± 331 mmHg% for GCW, 78.5 mmHg% (53-122) for GWW and a GWE of 96% (94-97), analyzed in 226 healthy, awake, and spontaneously breathing subjects.
Myocardial work of the systemic right ventricle and its association with outcomes
2024, International Journal of Cardiovascular Imaging
Drs Truong, and Vo contributed equally to this report.
Thomas H. Marwick, MBBS, PhD, MPH, MD, served as guest editor for this report.
Conflicts of interest: None.