Translational research

DOI: 10.4244/EIJ-D-22-00769

A bench study of balloon-expandable valves for the treatment of self-expanding valve failure

Mariama Akodad1,2,3,4, MD, PhD; David Meier1,2,3, MD; Stephanie Sellers1,2,3, PhD; Ole De Backer5, MD; Darren Mylotte6, MD; Uri Landes7, MD; Chris Frawley8, BEng; Lisa Lynch8, MSc; Gilbert H.L. Tang9, MD, MSc, MBA; Lars Sondergaard5, MD, DMSc; David A. Wood1,2,3, MD; John G. Webb1,2,3, MD; Janarthanan Sathananthan1,2,3, MBChB, MPH

Abstract

Background: Coronary obstruction and access are concerns in patients undergoing redo transcatheter aortic valve implantation (TAVI).

Aims: We sought to assess the neoskirt height, leaflet overhang, leaflet deflection,and transcatheter heart valve (THV) expansion and performance, at 2 different implant depths, of the SAPIEN 3 Ultra (S3U) within the ACURATE neo2 (ACn2) THV.

Methods: An in vitro study was performed with a 23 mm S3U deployed within a small (S) ACn2 and a 26 mm S3U deployed within a medium (M) and a large (L) ACn2. The S3U outflow was positioned at the top of the ACn2 crown (low implant) and at the base of the commissural post of the ACn2 (high implant). Testing was performed under physiological conditions as per ISO-5840-3 standard.

Results: The neoskirt height was shorter when the S3U outflow was positioned at a low implantation depth (S: 9.6 mm, M: 12.2 mm, L: 13.8 mm vs S: 15.2 mm, M: 15.1 mm, L: 17.8 mm ACn2 for high implants). Hydrodynamic performance was acceptable for all configurations. Leaflet overhang was <50% for all configurations except the...

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Volume 19 Number 1
May 12, 2023
Volume 19 Number 1
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