COMPETENCY IN MEDICAL KNOWLEDGE: As a promising imaging modality
Original ResearchIn Vivo Coronary 18F-Sodium Fluoride Activity: Correlations With Coronary Plaque Histological Vulnerability and Physiological Environment
Central Illustration
Section snippets
Study population
There were 569 coronary artery disease (CAD) patients who were scheduled for coronary artery bypass grafting (CABG)15 in Beijing Anzhen hospital between February 2018 and October 2021. Inclusion in this study required that patients were scheduled for CABG with adjunctive coronary endarterectomy (CE). Patients were excluded from this study for the following reasons: 1) a recent myocardial infarction (<4 weeks); 2) history of malignancy, acute or chronic inflammatory, and autoimmune disease; 3)
Patient characteristics
We included 55 specimens from 42 patients. Patients were predominantly elder men with multiple cardiovascular risk factors (Table 1). In total 52 specimens from 39 patients were used for pathological analysis. Three specimens from 3 patients were used for ex vivo 18F-NaF micro-PET/CT scan and radioactivity measurement. No significant difference was observed in clinical characteristics between patients with higher TBR and lower TBR (Supplemental Table 3).
Reproducibility assessment
For interobserver variability,
Discussion
In this study, we found the specificity and sensitivity of coronary 18F-NaF activity in detecting high-risk plaques and coronary 18F-NaF activity was significantly correlated with ex-vivo plaque vulnerable features of histology. In addition, the chemisorption of 18F-NaF within the plaque was related to intraplaque inflammation. In vivo coronary 18F-NaF activity was associated with high-risk features on coronary CTA. Thus, although most of the coronary atherosclerotic plaque ruptures do not lead
Conclusions
In vivo coronary 18F-NaF activity was significantly associated with ex-vivo coronary plaques histological vulnerability. Coronary 18F-NaF activity potentially provided discriminatory value for high-risk plaque. The vascular 18F-NaF activity was associated with the physiological environment of inflammation. Further studies with clinical outcomes are warranted to determine the prognostic significance of the coronary 18F-NaF activity.
Funding Support and Author Disclosures
This study was funded by the Key Medical Specialty Program of Sailing Plans organized by Beijing Municipal Administration of Hospitals (grant numbers: ZYLX202110), the National Natural Science Foundation of China (grant numbers: 81871377, 81571717), and the Research on Clinical Characteristics of Capital (grant number: Z181100001718071). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Acknowledgments
The authors express their gratitude to Drs Lei Xu, Wei Yu, Rui Wang, and Zhen Zhou, Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, for their advice on improving the manuscript.
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Drs Wen and Gao contributed equally to this work.