Elsevier

JACC: Cardiovascular Imaging

Volume 15, Issue 12, December 2022, Pages 2127-2138
JACC: Cardiovascular Imaging

Editorials and Viewpoints
The Future of Cardiac Magnetic Resonance Clinical Trials

https://doi.org/10.1016/j.jcmg.2021.07.029Get rights and content
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Abstract

Over the past 2 decades, cardiac magnetic resonance (CMR) has become an essential component of cardiovascular clinical care and contributed to imaging-guided diagnosis and management of coronary artery disease, cardiomyopathy, congenital heart disease, cardio-oncology, valvular, and vascular disease, amongst others. The widespread availability, safety, and capability of CMR to provide corresponding anatomical, physiological, and functional data in 1 imaging session can improve the design and conduct of clinical trials through both a reduction of sample size and provision of important mechanistic data that may augment clinical trial findings. Moreover, prospective imaging-guided strategies using CMR can enhance safety, efficacy, and cost-effectiveness of cardiovascular pathways in clinical practice around the world. As the future of large-scale clinical trial design evolves to integrate personalized medicine, cost-effectiveness, and mechanistic insights of novel therapies, the integration of CMR will continue to play a critical role. In this document, the attributes, limitations, and challenges of CMR’s integration into the future design and conduct of clinical trials will also be covered, and recommendations for trialists will be explored. Several prominent examples of clinical trials that test the efficacy of CMR-imaging guided pathways will also be discussed.

Key Words

cardiac magnetic resonance
clinical trials

Cited by (0)

Erik Schelbert, MD, served as Guest Editor for this work.

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