The Present and FutureJACC State-of-the-Art ReviewInflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review
JACC State-of-the-Art Review
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Central Illustration
Key Words
atrial fibrillation
inflammation
interleukins
NLRP3 inflammasome
Abbreviations and Acronyms
AF
atrial fibrillation
ASC
apoptosis-associated speck-like protein containing a CARD
CaMKII
calcium/calmodulin dependent protein kinase II alpha
CASP1
caspase 1
DM
diabetes mellitus
EAT
epicardial adipose tissue
IFN
interferon
IL
interleukin
IL-1R
interleukin 1 receptor
IP3
inositol triphosphate
NADPH
nicotinamide adenine dinucleotide phosphate
NF-κB
nuclear factor kappa light chain enhancer of activated B cells
NLR
nod-like receptor
NLRP1/3/4/6/12
NLR family pyrin domain containing 1/3/4/6/12
RNS
reactive nitrogen species
ROS
reactive oxygen species
RYR2
ryanodine receptor 2
SAT
subcutaneous adipose tissue
SR
sarcoplasmic reticulum
STAT3
signal transducer and activator of transcription 3
TAC
transverse aortic constriction
TGF
transforming growth factor
TLR
toll-like receptor
TNF
tumor necrosis factor
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Drs Lip and Ren contributed equally to this work as senior authors.
© 2022 by the American College of Cardiology Foundation. Published by Elsevier.