A Post-Pandemic Enigma: The Cardiovascular Impact of Post-Acute Sequelae of SARS-CoV-2

Circ Res. 2023 May 12;132(10):1358-1373. doi: 10.1161/CIRCRESAHA.122.322228. Epub 2023 May 11.

Abstract

COVID-19 has become the first modern-day pandemic of historic proportion, affecting >600 million individuals worldwide and causing >6.5 million deaths. While acute infection has had devastating consequences, postacute sequelae of SARS-CoV-2 infection appears to be a pandemic of its own, impacting up to one-third of survivors and often causing symptoms suggestive of cardiovascular phenomena. This review will highlight the suspected pathophysiology of postacute sequelae of SARS-CoV-2, its influence on the cardiovascular system, and potential treatment strategies.

Keywords: COVID-19; SARS-CoV-2; infections; pandemics; survivors.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • COVID-19*
  • Cardiovascular System*
  • Disease Progression
  • Humans
  • Lung
  • Pandemics
  • SARS-CoV-2