In older adults with hypertension, chlorthalidone vs. hydrochlorothiazide did not reduce major CV events or deaths at 2.4 y

Ann Intern Med. 2023 Apr;176(4):JC39. doi: 10.7326/J23-0018. Epub 2023 Apr 4.

Abstract

Diuretic Comparison Project Writing Group; Ishani A, Cushman WC, Leatherman SM, et al. Chlorthalidone vs. hydrochlorothiazide for hypertension-cardiovascular events. N Engl J Med. 2022;387:2401-10. 36516076.

Publication types

  • Comment

MeSH terms

  • Aged
  • Antihypertensive Agents / adverse effects
  • Chlorthalidone* / therapeutic use
  • Diuretics / adverse effects
  • Humans
  • Hydrochlorothiazide / therapeutic use
  • Hypertension* / complications
  • Hypertension* / drug therapy

Substances

  • Chlorthalidone
  • Hydrochlorothiazide
  • Antihypertensive Agents
  • Diuretics