In pituitary adenoma surgery, no vs. perioperative hydrocortisone was noninferior for new-onset adrenal insufficiency

Ann Intern Med. 2023 Apr;176(4):JC46. doi: 10.7326/J23-0013. Epub 2023 Apr 4.

Abstract

Guo X, Zhang D, Pang H, et al. Safety of withholding perioperative hydrocortisone for patients with pituitary adenomas with an intact hypothalamus-pituitary-adrenal axis: a randomized clinical trial. JAMA Netw Open. 2022;5:e2242221. 36383383.

Publication types

  • Randomized Controlled Trial
  • Comment

MeSH terms

  • Adenoma* / surgery
  • Adrenal Insufficiency* / drug therapy
  • Glucocorticoids / adverse effects
  • Humans
  • Hydrocortisone / therapeutic use
  • Hypothalamo-Hypophyseal System
  • Pituitary Neoplasms* / surgery

Substances

  • Hydrocortisone
  • Glucocorticoids