Leaflet Morphology and its Implications for Direct Transcatheter Annuloplasty of Tricuspid Regurgitation

JACC Cardiovasc Interv. 2023 Mar 27;16(6):693-702. doi: 10.1016/j.jcin.2023.01.364.

Abstract

Background: Leaflet morphology has been associated with treatment success in edge-to-edge repair of tricuspid regurgitation (TR), but the impact on annuloplasty is unclear.

Objectives: The authors sought to examine the association of leaflet morphology with efficacy and safety of direct annuloplasty in TR.

Methods: The authors analyzed patients who underwent catheter-based direct annuloplasty with the Cardioband at 3 centers. Leaflet morphology was assessed according to number and location of leaflets by echocardiography. Patients with simple morphology (2 or 3 leaflets) were compared with complex morphology (>3 leaflets).

Results: The study included 120 patients (median age 80 years) with ≥severe TR. A total of 48.3% of patients had a 3-leaflet morphology, 5% a 2-leaflet morphology, and 46.7% had >3 tricuspid leaflets. Baseline characteristics did not differ relevantly between groups except for a higher incidence of torrential TR grade (50 vs 26.6%) in complex morphologies. Postprocedural improvement of 1 (90.6% vs 92.9%) and 2 (71.9% vs 67.9%) TR grades was not significantly different between groups, but patients with complex morphology had more often residual TR ≥3 at discharge (48.2 vs 26.6%; P = 0.014). This difference did not remain significant (P = 0.112) after adjusting for baseline TR severity, coaptation gap, and nonanterior jet localization. Safety endpoints including complications of the right coronary artery, and technical success did not show significant differences.

Conclusions: Efficacy and safety of transcatheter direct annuloplasty using Cardioband are not affected by leaflet morphology. Assessment of leaflet morphology should be part of procedural planning in patients with TR and might help to individually tailor repair techniques to patient anatomy.

Keywords: functional tricuspid regurgitation; transcatheter treatment of functional tricuspid regurgitation; tricuspid leaflet morphology.

MeSH terms

  • Aged, 80 and over
  • Echocardiography / adverse effects
  • Humans
  • Mitral Valve / surgery
  • Treatment Outcome
  • Tricuspid Valve / diagnostic imaging
  • Tricuspid Valve / surgery
  • Tricuspid Valve Insufficiency* / diagnostic imaging
  • Tricuspid Valve Insufficiency* / etiology
  • Tricuspid Valve Insufficiency* / surgery