The next generation of evidence-based medicine

Nat Med. 2023 Jan;29(1):49-58. doi: 10.1038/s41591-022-02160-z. Epub 2023 Jan 16.

Abstract

Recently, advances in wearable technologies, data science and machine learning have begun to transform evidence-based medicine, offering a tantalizing glimpse into a future of next-generation 'deep' medicine. Despite stunning advances in basic science and technology, clinical translations in major areas of medicine are lagging. While the COVID-19 pandemic exposed inherent systemic limitations of the clinical trial landscape, it also spurred some positive changes, including new trial designs and a shift toward a more patient-centric and intuitive evidence-generation system. In this Perspective, I share my heuristic vision of the future of clinical trials and evidence-based medicine.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19*
  • Clinical Trials as Topic
  • Evidence-Based Medicine
  • Humans
  • Machine Learning
  • Pandemics