Statins increase muscle pain or weakness at 1 y, with an absolute excess of 11 events/1000 person-y

Ann Intern Med. 2023 Jan;176(1):JC4. doi: 10.7326/J22-0101. Epub 2023 Jan 3.

Abstract

Cholesterol Treatment Trialists' Collaboration. Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials. Lancet. 2022;400:832-45. 36049498.

Publication types

  • Meta-Analysis
  • Comment

MeSH terms

  • Cholesterol
  • Double-Blind Method
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors* / adverse effects
  • Myalgia* / chemically induced
  • Randomized Controlled Trials as Topic

Substances

  • Cholesterol
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors