Efforts to Improve Survival Outcomes of Out-of-Hospital Cardiac Arrest in China: BASIC-OHCA

Xi Xie; Jiaqi Zheng; Wen Zheng; Chang Pan; Yu Ma; Yimin Zhu; Huiqiong Tan; Xiaotong Han; Shengtao Yan; Guoqiang Zhang; Chaoqian Li; Fei Shao; Chunyi Wang; Jianbo Zhang; Yuan Bian; Jingjing Ma; Kai Cheng; Rugang Liu; Shaowei Sang; Yongsheng Zhang; Bryan McNally; Marcus E H Ong; Chuanzhu Lv; Yuguo Chen; Feng Xu; BASIC-OHCA Coordinators and Investigators

doi:10.1161/CIRCOUTCOMES.121.008856

Efforts to Improve Survival Outcomes of Out-of-Hospital Cardiac Arrest in China: BASIC-OHCA

Circ Cardiovasc Qual Outcomes. 2023 Feb;16(2):e008856. doi: 10.1161/CIRCOUTCOMES.121.008856. Epub 2022 Dec 12.

Authors

Xi Xie^#^{1

2}, Jiaqi Zheng^#¹, Wen Zheng^#¹, Chang Pan¹, Yu Ma³, Yimin Zhu^{1

4}, Huiqiong Tan⁵, Xiaotong Han⁴, Shengtao Yan⁶, Guoqiang Zhang⁶, Chaoqian Li⁷, Fei Shao^{8

9

10}, Chunyi Wang¹, Jianbo Zhang¹, Yuan Bian¹, Jingjing Ma¹, Kai Cheng¹, Rugang Liu¹, Shaowei Sang¹¹, Yongsheng Zhang¹, Bryan McNally¹², Marcus E H Ong¹³, Chuanzhu Lv², Yuguo Chen¹, Feng Xu¹; BASIC-OHCA Coordinators and Investigators

Affiliations

¹ Department of Emergency Medicine, Chest Pain Center, Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, The Key Laboratory of Cardiovascular Remodeling and Function Research affiliated to Chinese Ministry of Education and Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital, Shandong University, Ji'nan, China (X.X., J. Zheng, W.Z., C.P., C.W., J. Zhang, Y.B., J.M., K.C., R.L., Y.Z., Y.C., F.X.).
² Emergency Medicine Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China (X.X., C.L.).
³ Department of Intensive Care Unit, Chongqing University Central Hospital, Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center, Chongqing, China (Y.M.).
⁴ Department of Emergency Medicine, Hunan Provincial Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, Hunan Provincial People's Hospital/The First Affiliated Hospital, Hunan Normal University, Changsha, China (Y.Z., X.H.).
⁵ Emergency and Intensive Care Center, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy Medical Sciences, Beijing, China (H.T.).
⁶ Department of Emergency Medicine, China-Japan Friendship Hospital, Beijing, China (S.Y., G.Z.).
⁷ Department of Emergency, First Affiliated Hospital of Guangxi Medical University, Nanning, China (C.L.).
⁸ Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China (F.S.).
⁹ Hebei Yanda Hospital, Langfang, China (F.S.).
¹⁰ China Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing, China (F.S.).
¹¹ Clinical Epidemiology Unit, Qilu Hospital, Shandong University, Ji'nan, China (S.S.).
¹² Atlanta, Georgia, USA (B.M.).
¹³ Department of Emergency Medicine, Singapore General Hospital, Singapore (M.E.H.O).

^# Contributed equally.

PMID: 36503279
DOI: 10.1161/CIRCOUTCOMES.121.008856

Abstract

Background: Establishing registries to collect demographic characteristics, processes of care, and outcomes of patients with out-of-hospital cardiac arrest (OHCA) can better understand epidemiological trends, measure care quality, and identify opportunities for improvement. This study aimed to describe the design, implementation, and scientific significance of a nationwide registry-the BASIC-OHCA (Baseline Investigation of Out-of-Hospital Cardiac Arrest)-in China.

Methods: BASIC-OHCA was designed as a prospective, multicenter, observational, population-based study. The BASIC-OHCA registry was developed based on Utstein templates. BASIC-OHCA includes all OHCA patients confirmed by emergency medical services (EMS) personnel regardless of age, sex, or cause. Patients declared dead at the scene by EMS personnel for any reasons are also included. To fully characterize an OHCA event, BASIC-OHCA collects data from 3 sources-EMS, the receiving hospital, and patient follow-up-and links them to form a single record. Once data entry is completed and quality is checked, individual identifiers are stripped from the record.

Results: Currently, 32 EMS agencies in 7 geographic regions contribute data to BASIC-OHCA. They are distributed in the urban and rural areas, covering ≈9% of the population of mainland China. Data collection started on August 1, 2019. By July 31, 2020, a total of 92 913 EMS-assessed OHCA patients were enrolled. Among 28969 (31.18%) EMS-treated OHCAs, the mean age was 65.79±17.36 years, and 68.35% were males. The majority of OHCAs (76.85%) occurred at home or residence. A shockable initial rhythm was reported in 5.43% of patients. Any return of spontaneous circulation, survival to hospital discharge, and favorable neurological outcome at hospital discharge were 5.98%, 1.15%, and 0.83%, respectively.

Conclusions: BASIC-OHCA is the first nationwide registry on OHCA in China. It can be used as a public health surveillance system and as a platform to produce evidence-based practices to help identify opportunities for improvement.

Registration: URL: https://www.

Clinicaltrials: gov; Unique identifier: NCT03926325.

Keywords: China; emergency medical services; out-of-hospital cardiac arrest; public health surveillance; registry.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Cardiopulmonary Resuscitation*
China
Emergency Medical Services*
Female
Humans
Male
Middle Aged
Out-of-Hospital Cardiac Arrest*
Prospective Studies
Registries

Associated data

ClinicalTrials.gov/NCT03926325