Impact of disposable syringes type choice on myocardial perfusion imaging procedures with [99mTc]Tc-tetrofosmin

J Nucl Cardiol. 2023 Aug;30(4):1399-1405. doi: 10.1007/s12350-022-03143-w. Epub 2022 Nov 9.

Abstract

Background: Residual activity in dispensing syringes is a problem that has been sporadically reported with various radiopharmaceuticals. Studies with [99mTc]Tc-tetrofosmin are non-consistent so far. The aim was to quantify the residual activity of [99mTc]Tc-tetrofosmin in different syringes in a clinical setting and to assess its impact on the clinical imaging procedure.

Methods: The residual activity of [99mTc]Tc-tetrofosmin was measured in 3 types of syringes: 3-part lubricated and non-lubricated syringes and 2-part syringe (n ≥ 30 for each syringe). The residual activity was located and quantified using a CzT SPECT camera and radio-counting then was correlated with different clinical parameters and processed by multiple linear regression analysis.

Results: Residual activity was different in all syringe types but lubricated syringes showed significantly higher levels with a mean ± SD of 26.12 ± 10.21% (P < .001). For these syringes, the residual activity was mainly located on the lubricated body. They also have a positive and significant impact on the standardized counting duration of patients' acquisitions.

Conclusion: Lubricated syringes with high residual activity should be avoided as they increase the risk of prolonging patient acquisition time and potentially increasing the risk of poor image quality.

Keywords: Myocardial perfusion imaging; adsorption; radiopharmaceuticals; syringes; tetrofosmin.

MeSH terms

  • Humans
  • Myocardial Perfusion Imaging*
  • Organophosphorus Compounds
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • Syringes*
  • Tomography, Emission-Computed, Single-Photon

Substances

  • Radiopharmaceuticals
  • Organophosphorus Compounds
  • Organotechnetium Compounds